Factors influencing culture positivity in pyogenic vertebral osteomyelitis patients with prior antibiotic exposure.
نویسندگان
چکیده
We conducted a retrospective cohort study to evaluate factors influencing tissue culture positivity in patients with pyogenic vertebral osteomyelitis exposed to antibiotics before diagnosis. Tissue culture was positive in 48.3% (28/58) of the patients, and the median antibiotic-free period was 1.5 days (range, 0.7 to 5.7 days). In a multivariate analysis, a higher C-reactive protein (CRP) level (adjusted odds ratio [aOR], 1.18; 95% confidence interval, 1.07 to 1.29) and open surgical biopsy (aOR, 6.33; 95% confidence interval, 1.12 to 35.86) were associated with tissue culture positivity.
منابع مشابه
Microbiologically and clinically diagnosed vertebral osteomyelitis: impact of prior antibiotic exposure.
We retrospectively reviewed medical records to identify the factors that affect the results of culture in patients with pyogenic vertebral osteomyelitis. In multivariate analysis, the presence of paravertebral abscess was associated with positive results of microbiologic culture. Prior antibiotic exposure, especially of longer duration, was strongly associated with negative results.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 59 4 شماره
صفحات -
تاریخ انتشار 2015